Fetal Growth Regulation.

NIH researchers identify key regulator of fetal growth in mice.

 


Fetal Growth Regulator Discovered

NIH researchers identify key regulator of fetal growth in mice.

Findings reveal new, developmental role for proteins that typically combat ancient viruses.

A protein called ZFP568 regulates an important fetal growth hormone called insulin-like growth factor 2 (Igf2), according to a mouse study led by researchers at the National Institutes of Health. The study is one of the first to show that KRAB-zinc finger proteins, which are well-known for silencing viral genes left over from ancient infections, can also play an essential role in fetal and placental development.

Using a mouse model that lacked ZFP568, a KRAB-zinc finger protein, researchers at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) found that ZFP568 suppresses a gene—Igf2—that is needed for balancing fetal and placental growth. The team discovered that ZFP568 prevented a placental version of Igf2 from being expressed too early, during a window of time soon after the embryo implants into the uterus. Precise expression of Igf2 is important because small changes in Igf2 levels can lead to under- and overgrowth conditions in people, such as Russell Silver syndrome and Beckwith-Wiedemann syndrome, respectively.

"ZFP568 is part of a large family of rapidly evolving proteins that play a role in recognizing and protecting the genome from ancient viruses that litter mammalian genomes," said Todd Macfarlan, Ph.D., the study's lead author and head of the Unit on Mammalian Epigenome Reprogramming at NICHD. "Our results underscore how KRAB-zinc finger proteins have evolved critical developmental functions, possibly as a byproduct of their primary role in genome defense."

In the study, fetal mice lacking ZFP568 failed to develop normally, suggesting that too much Igf2 is toxic in early development. The researchers also found that mammals, including humans, have ZPF568-like proteins, indicating that its Igf2 suppression may have played an important role in the early evolution of mammals. The study team is exploring whether ZFP568 has a similar function in humans and whether other KRAB-zinc finger proteins have evolved to aid in other essential, developmental processes.


Posted 5/30/17

 

Scheduled Events

  Seussical   (9/6-15)
  2001 Space Odyssey   (9/7)
  Muster in the Mountains   (9/7-9)
  Wingzilla   (9/8)
  Canzoniere Grecanico Salentino   (9/9)
  Things [Mom] Taught Me   (9/13-23)
  Reach the Beach   (9/14-15)
  WM Storytelling Festival   (9/14-16)
  Metallak Race   (9/15)
  Mandeville & Richards   (9/15)
  Cohase Film Slam   (9/16)
  Tricycle Grand Prix  (9/16)
  Rodney Crowell   (9/21)
  NH Highland Games   (9/21-23)
  Don Who   (9/22)
  Harvest Celebration   (9/22)
  Health & Wellness Fair   (9/22)
  Jeep Invasion  (9/22)
  Lakes Region Tri Festival   (9/22-23)
  Pat Metheny   (9/26)
  Driving Miss Daisy   (9/27 - 10/6)
  Neko Case   (9/27)
  Shot of JD   (9/28)
  Dixville Half Marathon   (9/29)
  New Hampshire Marathon   (9/29)
  Matthew Odell   (9/30)
  Lincoln Fall Craft Festival   (10/6&7)
  Sparrow Blue & Crowes Pasture   (10/6)
  Oktoberfest  (10/6-7)
  White Mountain Oktoberfest   (10/6-7)
  Fall Foliage Celebration   (10/6-8)
  Sandwich Fair   (10/6-8)
  Paddle the Border   (10/7)
  Lincoln Fall Craft Festival   (10/7-9)
  Shadow Play   (10/10)
  Killer Joe   (10/11-21)
  Greg Brown   (10/12)
  Camping & RV Show   (10/12-14)
  Riverfire & Horrorfest   (10/13)
  Jay Stollman Band   (10/19)
  Murder Dinner Train   (10/19-20)
  Pumpkin Patch Express   (10/19-21)
  All Things Pumpkin   (10/20)
  Ethan Setiawan Band   (10/20)
  Bettye LaVette   (10/26)
  Murder Dinner Train   (10/26-27)
  Pumpkin Patch Express   (10/26-28)
  Berlin Jazz   (10/27)

 ◄ Expanded Calendar ►



Photo Galleries

 

Miss Berlin-Gorham Competition 2012 New England Brewfest 2014 RiverFire, Berlin, NH 2012 Sugar Hill Lupine Festival Gallery 2012 Bristol-Gorham Foliage
Quick Links

 






Business Directory

 

 

                      more ►  

 

 

Attractions

 


Area Attractions opening/closing schedules.


  Alpine Adventures
  Clark's Trading Post
  Cog Railway
  Conway Scenic Railroad
  Flume
  Fort Jefferson Fun Park
  Jericho Mountain ATV Park
  Kancamagus Highway
  Littleton Riverwalk
  Lost River Gorge
  Mountain Meadow Funplex
  Mt. Washington Auto Road
  Polar Caves
  Santa's Village
  Storyland
  Vertical Ventures
  Whale's Tail Water Park
  Woodstock Inn & Brewery

 

more ►  

 

Community Profiles

 

  Bethlehem
  Bretton Woods
  Colebrook
  Conway
  Franconia
  Gorham
  Hanover
  Jackson
  Lebanon
  Lincoln
  Littleton
  North Conway
  Pittsburg
  Plymouth
  Twin Mountain
  Whitefield
  Wolfeboro

more ►  

 

Recreation and Tourism

 

  25 Great Summer Adventures
  Farm To Table Restaurants
  Hiking To Crash Sites
  Little Ski Areas
  Local Movie Theaters
  Local Performance Theaters
  Moose Tours

 

more ►  

 

Other Resources

  NH Cabins & Cottages
  NH Census Info
  NH Data (OEP)
  NH Fishing Reports
  NH Foliage Report
  NH Hiking Trail Conditions
  NH Lottery
  NH Movie Guide
  NH Road Conditions
  NH Ski Reports
  NH Snowmobile Trail Reports
  NH State Parks
  NH Town Officials Directory
  NH Weather
  Summer Safety Tips [.pdf]
  White Mtn. National Forest
  VisitNH.Gov

 

 

 

Copyright 2012-2018 by George C. Jobel, 603-491-4340. All Rights Reserved.