NIH completes genomic analysis of 33 cancer types.

NH Healthwatch Articles: NIH completes genomic analysis.


NIH Completes Genomic
Analysis of 33 Cancer Types.
Data set includes molecular and clinical information from over 10,000 tumors.

Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas, on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer.

"This project is the culmination of more than a decade of groundbreaking work," said NIH Director Francis S. Collins, M.D., Ph.D. NIH completes in-depth genomic analysis of 33 cancer types.

"This analysis provides cancer researchers with unprecedented understanding of how, where and why tumors arise in humans, enabling better informed clinical trials and future treatments."

The PanCancer Atlas, published as a collection of 27 papers across a suite of Cell journals, sums up the work accomplished by The Cancer Genome Atlas (TCGA) - a multi-institution collaboration initiated and supported by the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both part of NIH. The program, with over $300 million in total funding, involved upwards of 150 researchers at more than two dozen institutions across North America.

"TCGA was the first project of its scale to characterize - at the molecular level - cancer across a breadth of cancer types," said Carolyn Hutter, Ph.D., director of NHGRI's Division of Genome Sciences and the NHGRI team lead for TCGA. "At the project's infancy 10 years ago, it wasn't even possible, much less on such a scale, to do the types of characterization and analysis that were being proposed. It was a hugely ambitious project."

"The PanCancer Atlas effort complements the over 30 tumor-specific papers that have been published by TCGA in the last decade and expands upon earlier pan-cancer work that was published in 2013 (link is external)," said Jean Claude Zenklusen, Ph.D., director of the TCGA Program Office at NCI.

The project focused not only on cancer genome sequencing, but also on different types of data analyses, such as investigating gene and protein expression profiles, and associating them with clinical and imaging data.

The PanCancer Atlas is divided into three main categories, each anchored by a summary paper that recaps the core findings for the topic. The main topics include cell of origin, oncogenic processes and oncogenic pathways. Multiple companion papers report in-depth explorations of individual topics within these categories.

In the first summary paper, the authors summarize the findings from a set of analyses that used a technique called molecular clustering, which groups tumors by parameters such as genes being expressed, abnormality of chromosome numbers in tumor cells and DNA modifications. The paper's findings suggest that tumor types cluster by their possible cells of origin, a result that adds to our understanding of how tumor tissue of origin influences a cancer's features and could lead to more specific treatments for various cancer types.

The second summary paper, presents a broad view of the TCGA findings on the processes that lead to cancer development and progression. Specifically, the authors noted that the findings identified three critical oncogenic processes: mutations, both germline (inherited) and somatic (acquired); the influence of the tumor's underlying genome and epigenome on gene and protein expression; and the interplay of tumor and immune cells. These findings will help prioritize the development of new treatments and immunotherapies for a wide range of cancers.

The final summary paper, details TCGA investigations on the genomic alterations in the signaling pathways that control cell cycle progression, cell death and cell growth, revealing the similarities and differences in these processes across a range of cancers. Their findings reveal new patterns of cancer's potential vulnerabilities that will aid in the development of combination therapies and personalized medicine.

The entire collection of papers comprising the PanCancer Atlas are available through a portal on cell.com (link is external). Additionally, as the decade-long TCGA effort wraps up, there will be a three-day symposium, TCGA Legacy: Multi-Omic Studies in Cancer (link is external), in Washington, D.C., September 27-29, 2018, that will discuss the future of large-scale cancer studies, with a session focusing on the PanCancer Atlas. The meeting will feature the latest advances on the genomic architecture of cancer and showcase recent progress toward therapeutic targeting.

About the National Human Genome Research Institute (NHGRI): NHGRI leads genomics research at the National Institutes of Health (NIH), providing technical expertise and guidance that benefit all institutes and centers. We share our groundbreaking science and vision with our colleagues in order to accelerate breakthroughs that improve lives. By collaborating with the scientific and medical communities, we catalyze the development of new genomic technologies and support the robust study and treatment of specific diseases throughout NIH. For more information about NHGRI and its programs, visit genome.gov.

About the National Cancer Institute (NCI): NCI leads the National Cancer Program and NIH's efforts to dramatically reduce the prevalence of cancer and improve the lives of cancer patients and their families, through research into prevention and cancer biology, the development of new interventions, and the training and mentoring of new researchers. For more information about cancer, please visit the NCI website at cancer.gov or call NCI's Contact Center (formerly known as the Cancer Information Service) at 1-800-4-CANCER (1-800-422-6237).

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.


Posted 4/5/18

 

Scheduled Events

Click here for Summer Series Events: concerts, films, etc.!)
(Click above for summer series events, concerts, film, etc.)


  The Little Mermaid   (7/10 - 8/6)
  The Foreigner   (7/11-30)
  We Have Always Lived...   (7/12-21)
  Always... Patsy Cline   (7/14 - 8/30)
  The Bel Airs   (7/19)
  Family Discovery Walk   (7/19)
  Fugitive Pieces   (7/19)
  Pete Kilpatrick   (7/19)
  Beauty & the Beast   (7/19 - 8/4)
  Torme Sings Torme   (7/20)
  Tom Papa   (7/20)
  Day Out With Thomas   (7/20-22)
  Seek the Peak   (7/20 & 21)
  Loon Festival   (7/21)
  Studio Two   (7/21)
  Circus Smirkus   (7/21 & 22)
  Mountain Bike Megabowl  (7/21 & 22)
  Albannach   (7/22)
  Bob Amos...   (7/22)
  Benefit Golf Tournament   (7/22)
  UVCB,   (7/23)
  Chicago   (7/23 - 8/31)
  Chanticleer   (7/24)
  Detour   (7/24)
  Tim & Dave Show  [.pdf]  (7/24)
  Peter Lawlor   (7/25)
  Colonial Meetinghouses   (7/25)
  Griff O'Brien   (7/25)
  Annie & the Orphans   (7/26)
  Annual Fundraiser   (7/26)
  The Hunts   (7/26)
  Dearly Beloveds  (7/26-29)
  Ossipee Valley Music Fest  (7/26-29)
  Laughing Stock   (7/26 - 8/4)
  Sounds in the Sanctuary   (7/27)
  Dustbowl Revival   (7/28)
  Hebron Church Fair   (7/28)
  ADAAWE   (7/29)
  Back Shed String Band   (7/29)
  The Moonlighters,   (7/30)
  East Bay Jazz  [.pdf]  (7/31)
  The Dean Machine   (7/31)
  Our Town   (7/31 - 8/29)
  Barnyard Incident   (8/1)
  Ingrid Husemoller   (8/1)
  Hester Street   (8/2)
  Rob Curto's Forro For All   (8/2)
  August, Osage County   (8/2-18)
  Ranky Tanky   (8/3)
  SitS: Anderson Jazz Trio   (8/3)
  Jericho ATV Festival   (8/3,4)
  The Hairy Man  (8/3,4)
  Freedom Old Home Week   (8/3-12)
  Love's Labor's Lost   (8/3-12)
  Tales of Hoffmann   (8/3-12)
  Blueberry Fest  (8/4)
  Krisanthi Sings  (8/4)
  Tanglewood Marionettes   (8/4)
  Top Notch Triathlon   (8/4)
  August First   (8/5)
  Touch-a-Truck   (8/5)
  Barber of Seville   (8/5-14)
  Lyme Town Band,   (8/6)
  Railroad's 44th Birthday   (8/6)
  Jose Duddy & BBQ   (8/7)
  Mo' Combo  [.pdf]  (8/7)
  Back Shed String Band   (8/8)
  Matt O'Dell   (8/8)
  66th Annual Penny Sale   (8/9)
  Acoustic Radio   (8/9)
  Ladysmith Black Mambazo   (8/9)
  And Then There Were None   (8/9-18)
  Seussical   (8/9-25)
  Spamalot   (8/9-27)
  The Doo Wop Project   (8/10)
  SitS: Borowsky Trio   (8/10)

 ◄ Expanded Calendar ►



Photo Galleries

 

Miss Berlin-Gorham Competition 2012 New England Brewfest 2014 RiverFire, Berlin, NH 2012 Sugar Hill Lupine Festival Gallery 2012 Bristol-Gorham Foliage
Quick Links

 






Business Directory

 

 

                      more ►  

 

 

Attractions

 


Area Attractions opening/closing schedules.


  Alpine Adventures
  Clark's Trading Post
  Cog Railway
  Conway Scenic Railroad
  Flume
  Fort Jefferson Fun Park
  Jericho Mountain ATV Park
  Kancamagus Highway
  Littleton Riverwalk
  Lost River Gorge
  Mountain Meadow Funplex
  Mt. Washington Auto Road
  Polar Caves
  Santa's Village
  Storyland
  Vertical Ventures
  Whale's Tail Water Park
  Woodstock Inn & Brewery

 

more ►  

 

Community Profiles

 

  Bethlehem
  Bretton Woods
  Colebrook
  Conway
  Franconia
  Gorham
  Hanover
  Jackson
  Lebanon
  Lincoln
  Littleton
  North Conway
  Pittsburg
  Plymouth
  Twin Mountain
  Whitefield
  Wolfeboro

more ►  

 

Recreation and Tourism

 

  25 Great Summer Adventures
  Farm To Table Restaurants
  Hiking To Crash Sites
  Little Ski Areas
  Local Movie Theaters
  Local Performance Theaters
  Moose Tours

 

more ►  

 

Other Resources

  NH Cabins & Cottages
  NH Census Info
  NH Data (OEP)
  NH Fishing Reports
  NH Foliage Report
  NH Hiking Trail Conditions
  NH Lottery
  NH Movie Guide
  NH Road Conditions
  NH Ski Reports
  NH Snowmobile Trail Reports
  NH State Parks
  NH Town Officials Directory
  NH Weather
  Summer Safety Tips [.pdf]
  White Mtn. National Forest
  VisitNH.Gov

 

 

 

Copyright 2012-2018 by George C. Jobel, 603-491-4340. All Rights Reserved.